Homeland Security Secretary Janet Napolitano, who has managed issues ranging from immigration to counter-terrorism, said Friday she is resigning.

President Obama had the following to say, "Since day one, Janet has led my administration's effort to secure our borders, deploying a historic number of resources, while also taking steps to make our immigration system fairer and more consistent with our values," continuing his comments, "And the American people are safer and more secure thanks to Janet's leadership in protecting our homeland against terrorist attacks."

The announcement caught many in Washington by surprise - As she has often been mentioned as a potential successor to Attorney General Eric Holder. Napolitano leaves the office to run the University of California and its system of colleges.